The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging.

ABSTRACT: An increased accumulation of immune-dysfunction-associated CD4⁺Foxp3⁺ regulatory T cells (T_regs) is observed in aging oral mucosa during infection. Here we studied the function of T_regs during oral cancer development in aging mucosa. First, we found heightened proportions of T_regs and myeloid-derived suppressor cells (MDSC) accumulating in mouse and human oral squamous cell carcinoma (OSCC) tissues. Using the mouse 4-Nitroquinoline 1-oxide(4-NQO) oral carcinogenesis model, we found that tongues of aged mice displayed increased propensity for epithelial cell dysplasia, hyperplasia, and accelerated OSCC development, which coincided with significantly increased abundance of IL-1β, T_regs, and MDSC in tongues. Partial depletion o

SUBMITTER: Bhaskaran N 

PROVIDER: S-EPMC8100664 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature