Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018.

ABSTRACT:

Importance

Spontaneous (nontraumatic) intracerebral hemorrhage (ICH) is the most severe complication of antithrombotic drug use.

Objectives

To estimate the strength of association between use of antithrombotic drugs and risk of ICH and to examine major changes in the incidence of ICH in the general population.

Design, setting, and participants

This case-control study of patients with a first-ever ICH from January 1, 2005, to December 31, 2018, matched by age, sex, and calendar year with general population controls (1:40 ratio), assessed case and control patients 20 to 99 years of age in population-based nationwide registries in Denmark (population of 5.8 million).

Exposures

Use of low-dose aspirin, clopidogrel, a vitamin K antagonist (VKA), or a direct oral ant

SUBMITTER: Hald SM 

PROVIDER: S-EPMC8100864 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature