Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice.

ABSTRACT:

Background

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and neuronal death. There are several well-established genetic and environmental factors hypothesized to contribute to AD progression including air pollution. However, the molecular mechanisms by which air pollution exacerbates AD are unclear.

Objective

This study explored the effects of particulate matter exposure on AD-related brain changes using the APP/PS1 transgenic model of disease.

Methods

Male C57BL/6;C3H wild type and APP/PS1 mice were exposed to either filtered air (FA) or particulate matter sized under 2.5μm (PM2.5) for 6 h/day, 5 days/week for 3 months and brains were collected. Immunohistochemistry

SUBMITTER: Sahu B 

PROVIDER: S-EPMC8100996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature