A fragment-based protein interface design algorithm for symmetric assemblies.

ABSTRACT: Theoretical and experimental advances in protein engineering have led to the creation of precisely defined, novel protein assemblies of great size and complexity, with diverse applications. One powerful approach involves designing a new attachment or binding interface between two simpler symmetric oligomeric protein components. The required methods of design, which present both similarities and key differences compared to problems in protein docking, remain challenging and are not yet routine. With the aim of more fully enabling this emerging area of protein material engineering, we developed a computer program, nanohedra, to introduce two key advances. First, we encoded in the program the construction rules (i.e. the search space parameters) that underlie all possible symmetric material c

SUBMITTER: Laniado J 

PROVIDER: S-EPMC8101011 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature