Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.

ABSTRACT:

Background

The objective of this study was to increase understanding of the complex interactions between diet, obesity, and the gut microbiome of adult female non-human primates (NHPs). Subjects consumed either a Western (n=15) or Mediterranean (n=14) diet designed to represent human dietary patterns for 31 months. Body composition was determined using CT, fecal samples were collected, and shotgun metagenomic sequencing was performed. Gut microbiome results were grouped by diet and adiposity.

Results

Diet was the main contributor to gut microbiome bacterial diversity. Adiposity within each diet was associated with subtle shifts in the proportional abundance of several taxa. Mediterranean diet-fed NHPs with lower body fat had a greater proportion of Lactobacillus animalis tha

SUBMITTER: Newman TM 

PROVIDER: S-EPMC8101030 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature