Limited haplotype diversity underlies polygenic trait architecture across 70 years of wheat breeding.

ABSTRACT:

Background

Selection has dramatically shaped genetic and phenotypic variation in bread wheat. We can assess the genomic basis of historical phenotypic changes, and the potential for future improvement, using experimental populations that attempt to undo selection through the randomizing effects of recombination.

Results

We bred the NIAB Diverse MAGIC multi-parent population comprising over 500 recombinant inbred lines, descended from sixteen historical UK bread wheat varieties released between 1935 and 2004. We sequence the founders' genes and promoters by capture, and the MAGIC population by low-coverage whole-genome sequencing. We impute 1.1 M high-quality SNPs that are over 99% concordant with array genotypes. Imputation accuracy only marginally improves when including th

SUBMITTER: Scott MF 

PROVIDER: S-EPMC8101041 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature