Anticancer drugs repurposed for Alzheimer's disease: a systematic review.

ABSTRACT:

Background

The relationship between cancer and dementia is triggering growing research interest. Several preclinical studies have provided the biological rationale for the repurposing of specific anticancer agents in Alzheimer's disease (AD), and a growing number of research protocols are testing their efficacy and safety/tolerability in patients with AD.

Methods

The aim of the present systematic review was to provide an overview on the repurposing of approved anticancer drugs in clinical trials for AD by considering both ongoing and completed research protocols in all phases. In parallel, a systematic literature review was conducted on PubMed, ISI Web, and the Cochrane Library to identify published clinical studies on repurposed anticancer agents in AD.

Results

Based

SUBMITTER: Ancidoni A 

PROVIDER: S-EPMC8101105 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature