Baseline spirometry parameters as predictors of airway hyperreactivity in adults with suspected asthma.

ABSTRACT:

Background

Methacholine challenge tests (MCTs) are used to diagnose airway hyperresponsiveness (AHR) in patients with suspected asthma where previous diagnostic testing has been inconclusive. The test is time consuming and usually requires referral to specialized centers. Simple methods to predict AHR could help determine which patients should be referred to MCTs, thus avoiding unnecessary testing. Here we investigated the potential use of baseline spirometry variables as surrogate markers for AHR in adults with suspected asthma.

Methods

Baseline spirometry and MCTs performed between 2013 and 2019 in a large tertiary center were retrospectively evaluated. Receiver-operating characteristic curves for the maximal expiratory flow-volume curve indices (angle β, FEV1, FVC, FEV1/F

SUBMITTER: Peled M 

PROVIDER: S-EPMC8101108 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature