The importance of transdiagnostic symptom level assessment to understanding prognosis for depressed adults: analysis of data from six randomised control trials.

ABSTRACT:

Background

Depression is commonly perceived as a single underlying disease with a number of potential treatment options. However, patients with major depression differ dramatically in their symptom presentation and comorbidities, e.g. with anxiety disorders. There are also large variations in treatment outcomes and associations of some anxiety comorbidities with poorer prognoses, but limited understanding as to why, and little information to inform the clinical management of depression. There is a need to improve our understanding of depression, incorporating anxiety comorbidity, and consider the association of a wide range of symptoms with treatment outcomes.

Method

Individual patient data from six RCTs of depressed patients (total n = 2858) were used to estimate the differ

SUBMITTER: O'Driscoll C 

PROVIDER: S-EPMC8101158 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature