Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway.

ABSTRACT:

Background

Fatty liver has become a main problem that causes huge economic losses in many aquaculture modes. It is a common physiological or pathological phenomenon in aquaculture, but the causes and occurring mechanism are remaining enigmatic.

Methods

Each three liver samples from the control group of allogynogenetic gibel carp with normal liver and the overfeeding group with fatty liver were collected randomly for the detailed comparison of histological structure, lipid accumulation, transcriptomic profile, latent pathway identification analysis (LPIA), marker gene expression, and hepatocyte mitochondria analyses.

Results

Compared to normal liver, larger hepatocytes and more lipid accumulation were observed in fatty liver. Transcriptomic analysis between fatty liver

SUBMITTER: Zhang XJ 

PROVIDER: S-EPMC8101161 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature