Immunoglobulin A nephropathy and ischemic heart disease: a nationwide population-based cohort study.

ABSTRACT:

Background

Chronic kidney disease has been linked to cardiovascular disease and specifically ischemic heart disease (IHD), but large-scale population data in patients with immunoglobulin A nephropathy (IgAN) are missing.

Objective

To examine absolute and relative risks for IHD in patients with IgAN.

Methods

Population-based register-based cohort study in Sweden. We identified 3945 patients with biopsy-verified IgAN, and 19,272 age- and sex-matched reference individuals from the general population. To reduce residual confounding from genetic factors and early environmental factors we carried out secondary analyses, where we compared 3039 IgAN patients with 6729 siblings, whereas a spousal analysis consisted of 2377 married couples where one of the spouses had IgAN. Dat

SUBMITTER: Jarrick S 

PROVIDER: S-EPMC8101187 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature