Iohexol plasma clearance for measuring glomerular filtration rate: effect of different ways to calculate the area under the curve.

ABSTRACT:

Background

Measuring glomerular filtration rate (GFR) using iohexol plasma clearance has been proposed as the preferred way for GFR determination. The extended multiple-sample protocol is based on fitting the full concentration-time decay-curve, and from the obtained fit-parameters, the area under the curve (AUC) and GFR (the injected dose divided by the AUC) were calculated. The goal of the current study is to evaluate the impact of different fitting procedures on the precision of GFR-results obtained from the full concentration-time curve, and compare these results with those obtained with simplified multiple-samples and single-sample protocols.

Methods

The concentration-time curves of 8 samples at times 30, 60, 90, 120, 150, 180, 240 and 300 min after bolus injection of i

SUBMITTER: Pottel H 

PROVIDER: S-EPMC8101203 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature