Recent advances in targeted drug delivery for treatment of osteoarthritis.

ABSTRACT:

Purpose of review

Osteoarthritis is associated with severe joint pain, inflammation, and cartilage degeneration. Drugs injected directly into intra-articular joint space clear out rapidly providing only short-term benefit. Their transport into cartilage to reach cellular targets is hindered by the tissue's dense, negatively charged extracellular matrix. This has limited, despite strong preclinical data, the clinical translation of osteoarthritis drugs. Recent work has focused on developing intra-joint and intra-cartilage targeting drug delivery systems (DDS) to enable long-term therapeutic response, which is presented here.

Recent findings

Synovial joint targeting hybrid systems utilizing combinations of hydrogels, liposomes, and particle-based carriers are in consideration

SUBMITTER: Mehta S 

PROVIDER: S-EPMC8101446 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature