Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach.

ABSTRACT:

Aim

The aim of this study was to integrate both coding and non-coding available microarray data in the development of colorectal cancer (CRC) with bioinformatics analyses to attain a more inclusive pathobiologic map of their molecular interactions and functions.

Background

Identification of competing endogenous RNAs (ceRNAs), especially circRNAs, has become a new hotspot in cancer research, although their roles and underlying mechanisms in CRC development remain mostly unknown.

Methods

Microarray data was retrieved from the Gene Expression Omnibus (GEO) database and analyzed. Several bioinformatics tools and databases were applied for further elucidation. Principal component analysis (PCA) was run separately for four datasets. The dysregulated circRNA-miRNA-mRNA, co-e

SUBMITTER: Kadkhoda S 

PROVIDER: S-EPMC8101520 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature