LINC01133 promotes hepatocellular carcinoma progression by sponging miR-199a-5p and activating annexin A2.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) are functionally associated with cancer development and progression. Although gene copy number variation (CNV) is common in hepatocellular carcinoma (HCC), it is not known how CNV in lncRNAs affects HCC progression and recurrence. We aimed to identify a CNV-related lncRNA involved in HCC progression and recurrence and illustrate its underlying mechanisms and prognostic value.

Methods

We analyzed the whole genome sequencing (WGS) data of matched cancerous and noncancerous liver samples from 49 patients with HCC to identify lncRNAs with CNV. The results were validated in another cohort of 238 paired HCC and nontumor samples by TaqMan copy number assay. We preformed Kaplan-Meier analysis and log-rank test to identify lncRNA CNV with prog

SUBMITTER: Yin D 

PROVIDER: S-EPMC8101537 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature