Heterogeneous magnitude of immunological memory to SARS-CoV-2 in recovered individuals.

ABSTRACT:

Objective

Although the adaptive immune response to SARS-CoV-2 has been characterised in the acute and early convalescent phase of the disease, few studies explore whether natural infection elicits long-lasting immunological memory in recovered individuals. In this work, we aimed to assess the maintenance of immunological memory to SARS-CoV-2.

Methods

We evaluated the long-term virus-specific cellular and humoral immune response in the members of an Italian Serie A football team, who experienced a cluster of COVID-19 in March 2020, which was strictly evaluated in the following months.

Results

Our results highlight a heterogeneous magnitude of immunological memory at 5 months after infection. Indeed, 20% of the subjects displayed a weak cellular and humoral memory to SA

SUBMITTER: Mazzoni A 

PROVIDER: S-EPMC8101693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature