Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages.

ABSTRACT: Bacterial infections are one of the main health concerns humanity faces today and bacterial resistances and protection mechanisms are set to aggravate the issue in the coming years. An increasing number of bacterial strains evades antibiotic treatment by hiding inside cells. Conventional antimicrobial agents are unable to penetrate or be retained in the infected mammalian cells. Recent approaches to overcome these limitations have focused on load-carrier systems, requiring a triggered discharge leading to complex release kinetics. The unison of potent antimicrobial activity with high mammalian cell compatibility is a prerequisite for intracellular activity, which is not well-met by otherwise well-established inorganic systems, such as silver-based nanoparticles. In this work, load and carr

SUBMITTER: Matter MT 

PROVIDER: S-EPMC8101700 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature