Clinical factors associated with rapid treatment of sepsis.

ABSTRACT:

Purpose

To understand what clinical presenting features of sepsis patients are historically associated with rapid treatment involving antibiotics and fluids, as appropriate.

Design

This was a retrospective, observational cohort study using a machine-learning model with an embedded feature selection mechanism (gradient boosting machine).

Methods

For adult patients (age ≥ 18 years) who were admitted through Emergency Department (ED) meeting clinical criteria of severe sepsis from 11/2007 to 05/2018 at an urban tertiary academic medical center, we developed gradient boosting models (GBMs) using a total of 760 original and derived variables, including demographic variables, laboratory values, vital signs, infection diagnosis present on admission, and historical comorbidit

SUBMITTER: Song X 

PROVIDER: S-EPMC8101717 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature