System biology and bioinformatics pipeline to identify comorbidities risk association: Neurodegenerative disorder case study.

ABSTRACT: Alzheimer's disease (AD) is the commonest progressive neurodegenerative condition in humans, and is currently incurable. A wide spectrum of comorbidities, including other neurodegenerative diseases, are frequently associated with AD. How AD interacts with those comorbidities can be examined by analysing gene expression patterns in affected tissues using bioinformatics tools. We surveyed public data repositories for available gene expression data on tissue from AD subjects and from people affected by neurodegenerative diseases that are often found as comorbidities with AD. We then utilized large set of gene expression data, cell-related data and other public resources through an analytical process to identify functional disease links. This process incorporated gene set enrichment analysis a

SUBMITTER: Chowdhury UN 

PROVIDER: S-EPMC8101720 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature