Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is the main complication of coronavirus disease 2019 (COVID-19), requiring admission to the intensive care unit (ICU). Despite extensive immune profiling of COVID-19 patients, to what extent COVID-19-associated ARDS differs from other causes of ARDS remains unknown. To address this question, here, we build 3 cohorts of patients categorized in COVID-19^-ARDS⁺, COVID-19⁺ARDS⁺, and COVID-19⁺ARDS^-, and compare, by high-dimensional mass cytometry, their immune landscape. A cell signature associating S100A9/calprotectin-producing CD169⁺ monocytes, plasmablasts, and Th1 cells is found in COVID-19⁺ARDS⁺, unlike COVID-19^-ARDS⁺ patients. M

SUBMITTER: Roussel M 

PROVIDER: S-EPMC8101789 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature