Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome.

ABSTRACT:

Background

Gastrointestinal problems affect the health and quality of life of individuals with Rett syndrome (RTT) and pose a medical hardship for their caregivers. We hypothesized that the variability in the RTT phenotype contributes to the dysbiosis of the gut microbiome and metabolome in RTT, predisposing these individuals to gastrointestinal dysfunction.

Objectives

We characterized the gut bacterial microbiome and metabolome in girls and young women with RTT (n = 44) and unaffected controls (n = 21), and examined the relation between the composition of the microbiome and variations in the RTT phenotype.

Methods

Demographics and clinical information, including growth and anthropometric measurements, pubertal status, symptoms, clinical severity score, bowel movement

SUBMITTER: Thapa S 

PROVIDER: S-EPMC8101921 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature