The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.

ABSTRACT:

Background

Understanding the epidemic of chronic kidney disease of uncertain etiology may be critical for health policies and public health responses. Recent studies have shown that microplastics (MPs) contaminate our food chain and accumulate in the gut, liver, kidney, muscle, and so on. Humans manufacture many plastics-related products. Previous studies have indicated that particles of these products have several effects on the gut and liver. Polystyrene (PS)-MPs (PS-MPs) induce several responses, such as oxidative stress, and affect living organisms.

Objectives

The aim of this study was to investigate the effects of PS-MPs in kidney cells in vitro and in vivo.

Methods

PS-MPs were evaluated in human kidney proximal tubular epithelial cells (HK-2 cells)

SUBMITTER: Wang YL 

PROVIDER: S-EPMC8101928 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature