A scheme for inferring viral-host associations based on codon usage patterns identifies the most affected signaling pathways during COVID-19.

ABSTRACT: Understanding the molecular mechanism of COVID-19 pathogenesis helps in the rapid therapeutic target identification. Usually, viral protein targets host proteins in an organized fashion. The expression of any viral gene depends mostly on the host translational machinery. Recent studies report the great significance of codon usage biases in establishing host-viral protein-protein interactions (PPI). Exploring the codon usage patterns between a pair of co-evolved host and viral proteins may present novel insight into the host-viral protein interactomes during disease pathogenesis. Leveraging the similarity in codon usage patterns, we propose a computational scheme to recreate the host-viral protein-protein interaction network. We use host proteins from seventeen (17) essential signaling path

SUBMITTER: Das JK 

PROVIDER: S-EPMC8102073 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature