Safety and Efficacy of Anticoagulation in Patients with Cirrhosis: A Meta-Analysis.

ABSTRACT:

Background and aims

Portal vein thrombosis is a serious adverse event that occurs during liver cirrhosis. We performed a meta-analysis to evaluate the safety and efficacy of anticoagulant therapy and prophylactic anticoagulant therapy in cirrhosis patients with (/without) portal vein thrombosis.

Methods

Eligible comparative studies were identified by searching the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, and CNKI. A meta-analysis was performed to calculate odds ratios and 95% confidence intervals using fixed-effects models. Recanalization and thrombus progression were defined as the primary outcomes. Secondary outcomes included adverse events and death mortality.

Results

A total of 3479 patients were included in this analysis.

SUBMITTER: Chen H 

PROVIDER: S-EPMC8102101 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature