Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.

ABSTRACT:

Introduction

Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations.

Methods

We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures.

Results

SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivari

SUBMITTER: Finsterwalder S 

PROVIDER: S-EPMC8102202 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature