MALAT1 gene rs600231 polymorphism positively associated with acute coronary syndrome in Chinese population: a case-control study.

ABSTRACT:

Background

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recognized as a major player in the pathogenesis of coronary artery disease (CAD). The aim of the study was to determine the association between polymorphisms of the MALAT1 gene and acute coronary syndrome (ACS) in a Chinese population in Xinjiang.

Methods

In the case-control study, we genotyped three nucleotide polymorphisms (rs3200401, rs4102217, rs600231) of the MALAT1 gene using SNPscan^TM typing assays (1,053 controls and 929 ACS patients). Furthermore, we explored a predictive model using MALAT1 rs600231 and clinical variables to predict the risk of ACS. Finally, the relative expression of long noncoding RNA (lncRNA) MALAT1 was also measured

SUBMITTER: Song N 

PROVIDER: S-EPMC8102249 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature