Formaldehyde and Brain Disorders: A Meta-Analysis and Bioinformatics Approach.

ABSTRACT: While there is significant investigation and investment in brain and neurodegenerative disease research, current understanding of the etiologies of illnesses like Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and brain cancer remains limited. Environmental exposure to the pollutant formaldehyde, an emerging neurotoxin widely used in industry, is suspected to play a critical role in mediating these disorders, although findings are limited and inconsistent. Focusing on highly exposed groups, we performed a meta-analysis of human epidemiological studies of formaldehyde and neurodegenerative disease (N =  19) or brain tumors (N = 12). To assess the biological plausibility of observed associations, we then conducted a bioinformatics analysis using Wiki

SUBMITTER: Rana I 

PROVIDER: S-EPMC8102312 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature