Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.

ABSTRACT:

Objectives

Studies have shown that people with HIV (PWH) may be at increased risk for chronic lung diseases and lung function abnormalities, which may be associated with immune activation. We tested the association of a panel of 12 immune activation and inflammation biomarkers with spirometry and single-breath diffusing capacity for carbon monoxide (DLco).

Design

Cross-sectional, observational study.

Methods

Participants were enrolled from the Inflammation, Aging, Microbes and Obstructive Lung Disease cohort of PWH at two US sites. Biomarkers were examined and standardized spirometry and DLco testing were performed. We tested associations between each biomarker and lung function, examined individually and in combination, using multi-variable linear and logistic regres

SUBMITTER: Jan AK 

PROVIDER: S-EPMC8102352 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature