Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans.

ABSTRACT:

Background

Androgen receptor signaling is crucial to prostate cancer aggressiveness. Members of the solute carrier family of the organic anion transporting peptides (SLCO) are potential regulators of androgen availability in prostate tissue. It remains unknown whether genetic variations in SLCOs contribute to the differences in prostate cancer aggressiveness in African Americans (AA) and European Americans (EA).

Methods

SNPs in 11 SLCO members were selected, with addition of 139 potentially functional SNPs and 128 ancestry informative markers. A total of 1,045 SNPs were genotyped and analyzed in 993 AAs and 1,057 EAs from the North Carolina-Louisiana Prostate Cancer Project. Expression and cellular localization of SLCOs were examined using qRT-PCR, IHC, and in situ RN

SUBMITTER: Tang L 

PROVIDER: S-EPMC8102354 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature