Drug resistance mutations in HIV provirus are associated with defective proviral genomes with hypermutation.

ABSTRACT:

Background

HIV proviral sequencing overcomes the limit of plasma viral load requirement by detecting all the 'archived mutations', but the clinical relevance remains to be evaluated.

Methods

We included 25 participants with available proviral sequences (both intact and defective sequences available) and utilized the genotypic sensitivity score (GSS) to evaluate the level of resistance in their provirus and plasma virus. Defective sequences were further categorized as sequences with and without hypermutations. Personalized GSS score and total GSS score were calculated to evaluate the level of resistance to a whole panel of antiretroviral therapies and to certain antiretroviral therapy that a participant was using. The rate of sequences with drug resistance mutations (DRMs) wi

SUBMITTER: Li Y 

PROVIDER: S-EPMC8102365 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature