Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis.

ABSTRACT: Spondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate immune system, following migration into affected tissue, may play a role in the pathogenesis of SpA. Here, potential associations between osteogenesis-linked gene expression profile in particular monocyte subpopulations and clinical signs of SpA were investigated. The 20 patients with axial and 16 with peripheral SpA were enrolled in the study. Monocyte subpopulations (classical-CD14⁺⁺CD16^-, intermediate-CD14⁺⁺CD16⁺ and non-classical-CD14⁺CD16⁺⁺) were isolated from blood using flow cytometry and gene expression analysis was performed using real-time PCR method and TaqMan A

SUBMITTER: Stec M 

PROVIDER: S-EPMC8102490 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature