IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4⁺ T cell responses.

ABSTRACT: Mast cells are potent mediators of allergy and asthma, yet their role in regulating adaptive immunity remains ambiguous. On the surface of mast cells, the crosslinking of IgE bound to FcεRI by a specific antigen recognized by that IgE triggers the release of immune mediators such as histamine and cytokines capable of activating other immune cells; however, little is known about the mast cell contribution to the induction of endogenous, antigen-specific CD4⁺ T cells. Here we examined the effects of specific mast cell activation in vivo on the initiation of an antigen-specific CD4⁺ T cell response. While CD4⁺ T cells were not enhanced by FcεRI stimulation alone, their activation was synergistically enhanced when FcεRI activation was combined with TLR4 stimula

SUBMITTER: Phong BL 

PROVIDER: S-EPMC8102524 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature