Smaller volume of posterior thalamic nuclei in patients with obsessive-compulsive disorder.

ABSTRACT:

Aim

Although the thalamus is a key structure in the pathophysiology of obsessive-compulsive disorder (OCD), reports regarding thalamic volume alterations in OCD patients have been inconsistent. Because the thalamus has a complex structure with distinct functions, we investigated subregional volume changes in the thalamus and their relationship with clinical attributes in a large sample of medication-free OCD patients.

Methods

We collected T1-weighted magnetic resonance imaging data from 177 OCD patients and 152 healthy controls (HCs). Using FreeSurfer, we segmented the thalamus into 12 nuclei groups; subregional volumes were compared between groups using an analysis of covariance. The relationships between altered thalamic volumes and OC symptom severity and OCD onset age we

SUBMITTER: Jurng J 

PROVIDER: S-EPMC8102624 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature