A case report of pregnancy in untreated alkaptonuria - Focus on urinary tissue remodelling markers.

ABSTRACT: A 34-year old woman with alkaptonuria had an elective pregnancy, during which she collected urine samples over the duration of her pregnancy until parturition. She had been attending the National Alkaptonuria Centre from the age of 31 years and continued to attend after delivery for a further three annual visits. Data from her NAC visits as well as urine samples collected during pregnancy were analysed. Urine CTX-1/urine creatinine, urine αCTX-I/ urine creatinine, urine CTX-II/ urine creatinine, and urine C3M/urine creatinine all showed a rapid increase early in pregnancy, returning to baseline before increasing in late pregnancy, indicating significant remodelling of bone, subchondral bone, cartilage and other organs and connective tissue rich in collagens I, II and III. The pattern of ti

SUBMITTER: Ranganath LR 

PROVIDER: S-EPMC8102796 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature