Resolution-Based Therapies: The Potential of Lipoxins to Treat Human Diseases.

ABSTRACT: Inflammation is an a physiological response instead an essential response of the organism to injury and its adequate resolution is essential to restore homeostasis. However, defective resolution can be the precursor of severe forms of chronic inflammation and fibrosis. Nowadays, it is known that an excessive inflammatory response underlies the most prevalent human pathologies worldwide. Therefore, great biomedical research efforts have been driven toward discovering new strategies to promote the resolution of inflammation with fewer side-effects and more specificity than the available anti-inflammatory treatments. In this line, the use of endogenous specialized pro-resolving mediators (SPMs) has gained a prominent interest. Among the different SPMs described, lipoxins stand out as one of t

SUBMITTER: Jaen RI 

PROVIDER: S-EPMC8102821 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature