Ontology highlight
ABSTRACT:
SUBMITTER: Moriya T
PROVIDER: S-EPMC8102907 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Moriya Taiki T Kitagawa Kurumi K Hayakawa Yuuki Y Hemmi Hiroaki H Kaisho Tsuneyasu T Ueha Satoshi S Ikebuchi Ryoyo R Yasuda Ippei I Nakanishi Yasutaka Y Honda Tetsuya T Matsushima Koji K Kabashima Kenji K Ueda Mizuki M Kusumoto Yutaka Y Chtanova Tatyana T Tomura Michio M
iScience 20210414 5
Immunogenic tumor cell death enhances anti-tumor immunity. However, the mechanisms underlying this effect are incompletely understood. We established a system to induce tumor cell death <i>in situ</i> and investigated its effect on dendritic cell (DC) migration and T cell responses using intravital photolabeling in mice expressing KikGR photoconvertible protein. We demonstrate that tumor cell death induces phagocytosis of tumor cells by tumor-infiltrating (Ti)-DCs, and HMGB1-TLR4 and ATP-P2X7 re ...[more]