Population-level diversity-disease relationship (p-DDR) in the human microbiome associated diseases.

ABSTRACT: Diversity-disease relationship (DDR) is a de facto standard analysis in the studies of human microbiome associated diseases (MADs). For example, the species richness or Shannon entropy are routinely compared between the healthy and diseased groups. Nevertheless, the basic scale of the standard diversity analysis is individual subject rather than a cohort or population because the diversity is computed for individual samples, not for the group. Here we aim to expand the current DDR study from individual focus to population level, which can offer important insights for understanding the epidemiology of MADs. We analyzed the diversity-disease relationship at cohort scale based on a collection of 23 datasets covering the major human MADs. Methodologically, we harness the power of a rece

SUBMITTER: Li W 

PROVIDER: S-EPMC8102914 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature