Extracytoplasmic Function σ Factors as Tools for Coordinating Stress Responses.

ABSTRACT: The ability of bacterial core RNA polymerase (RNAP) to interact with different σ factors, thereby forming a variety of holoenzymes with different specificities, represents a powerful tool to coordinately reprogram gene expression. Extracytoplasmic function σ factors (ECFs), which are the largest and most diverse family of alternative σ factors, frequently participate in stress responses. The classification of ECFs in 157 different groups according to their phylogenetic relationships and genomic context has revealed their diversity. Here, we have clustered 55 ECF groups with experimentally studied representatives into two broad classes of stress responses. The remaining 102 groups still lack any mechanistic or functional insight, representing a myriad of systems yet to explore. In this work

SUBMITTER: de Dios R 

PROVIDER: S-EPMC8103513 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature