Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food.

ABSTRACT: Animal experiments have demonstrated that diets high in fats create a harmful environment for developing sperm cells, contributing to impaired reproductive health and induced risk for chronic diseases in the next generation. Changes at the level of the epigenome have been suggested to underlie these observations. Human data are limited to verify this hypothesis. While we earlier demonstrated a link between male obesity and DNA methylation changes at imprinted genes in mature sperm cells and newborns, it is currently unknown if -or how- a paternal eating pattern (related to obesity) is related to indices for epigenetic inheritance. We here aim to examine a yet unexplored link between consumption of healthy (rich in vitamins and fibers) or unhealthy ("fast") foods and methylation at imprint

SUBMITTER: Soubry A 

PROVIDER: S-EPMC8103543 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature