Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue.

ABSTRACT:

Background

Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia pipientis are less susceptible than wild-type A. aegypti to dengue virus infection.

Methods

We conducted a cluster-randomized trial involving releases of wMel-infected A. aegypti mosquitoes for the control of dengue in Yogyakarta, Indonesia. We randomly assigned 12 geographic clusters to receive deployments of wMel-infected A. aegypti (intervention clusters) and 12 clusters to receive no deployments (control clusters). All clusters practiced local mosquito-control measures as usual. A test-negative design was used to assess the efficacy of the intervention. Patients with acute undifferentiated fever who presented to local primary care clinics

SUBMITTER: Utarini A 

PROVIDER: S-EPMC8103655 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature