Novel Lytic Phages Protect Cells and Mice against Pseudomonas aeruginosa Infection.

ABSTRACT: With the fast emergence of serious antibiotic resistance and the lagged discovery of novel antibacterial drugs, phage therapy for pathogenic bacterial infections has acquired great attention in the clinics. However, development of therapeutic phages also faces tough challenges, such as laborious screening and time to generate effective phage drugs since each phage may only lyse a narrow scope of bacterial strains. Identifying highly effective phages with broad host ranges is crucial for improving phage therapy. Here, we isolated and characterized several lytic phages from various environments specific for Pseudomonas aeruginosa by testing their growth, invasion, host ranges, and potential for killing targeted bacteria. Importantly, we identified several therapeutic phages (HX1, PPY9

SUBMITTER: Chen F 

PROVIDER: S-EPMC8103703 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature