A new mechanistic approach for the treatment of chronic neuropathic pain with nitrous oxide integrated from a systems biology narrative review.

ABSTRACT: The limitations of the currently available treatments for chronic neuropathic pain highlight the need for safer and more effective alternatives. The authors carried out a focused review using a systems biology approach to integrate the complex mechanisms of nociception and neuropathic pain, and to decipher the effects of nitrous oxide (N₂O) on those pathways, beyond the known effect of N₂O on N-methyl-D-aspartate receptors. This review identified a number of potential mechanisms by which N₂O could impact the processes involved in peripheral and central sensitization. In the ascending pathway, the effects of N₂O include activating TWIK-related K⁺ channel 1 potassium channels on first-order neurons, blocking voltage-dependent calcium cha

SUBMITTER: Bessiere B 

PROVIDER: S-EPMC8103977 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature