Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes.

ABSTRACT: The gut bacterial community prevents many pathogens from colonizing the intestine. Previous studies have associated specific bacteria with clearing Clostridioides difficile colonization across different community perturbations. However, those bacteria alone have been unable to clear C. difficile colonization. To elucidate the changes necessary to clear colonization, we compared differences in bacterial abundance between communities able and unable to clear C. difficile colonization. We treated mice with titrated doses of antibiotics prior to C. difficile challenge, resulting in no colonization, colonization and clearance, or persistent colonization. Previously, we observed that clindamycin-treated mice were susceptible to colonization but spontaneously cleared <

SUBMITTER: Lesniak NA 

PROVIDER: S-EPMC8103992 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature