Reduced Mortality Associated With the Use of Metformin Among Patients With Autoimmune Diseases.

ABSTRACT:

Objective

Metformin has been linked to anti-proliferative and anti-inflammatory mechanisms. In this study, we aimed to examine the long-term impact of metformin on mortality and organ damage in patients with autoimmune diseases and type 2 diabetes mellitus (T2DM).

Methods

We conducted a cohort study using the National Health Insurance Research Database in Taiwan between 1997 and 2013. Based on metformin and other anti-diabetic agent prescriptions, we categorized all patients with autoimmune diseases into either the metformin group (metformin administration for at least 28 days) or the non-metformin group. The primary outcomes were all-cause mortality and annual admission rate, while the secondary outcome was target organ damage. We followed patients from the index date to th

SUBMITTER: Lin CY 

PROVIDER: S-EPMC8104028 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature