TCR Signal Strength and Antigen Affinity Regulate CD8⁺ Memory T Cells.

ABSTRACT: CD8⁺ T cells play a critical role in adaptive immunity, differentiating into CD8⁺ memory T cells that form the basis of protective cellular immunity. Vaccine efficacy is attributed to long-term protective immunity, and understanding the parameters that regulate development of CD8⁺ T cells is critical to the design of T cell-mediated vaccines. We show in this study using mouse models that two distinct parameters, TCR signal strength (regulated by the tyrosine kinase ITK) and Ag affinity, play important but separate roles in modulating the development of memory CD8⁺ T cells. Unexpectedly, our data reveal that reducing TCR signal strength along with reducing Ag affinity for the TCR leads to enhanced and accelerated development of CD8⁺ mem

SUBMITTER: Solouki S 

PROVIDER: S-EPMC8104072 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature