High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model.

ABSTRACT:

Objective

Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman primates.

Methods

Four rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In group I (n = 2), catheters were externalized and lumbar drain catheters were placed simultaneously to assess CSF distribution after short-term infusions. MTX110 (0.5 ml of 300 μM panobinostat solution) was infused into the fourth ventricle daily for 5 consecutive days. Serial CSF and serum panobinostat levels were measured. In group

SUBMITTER: Sandberg DI 

PROVIDER: S-EPMC8104457 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature