Circulating extracellular vesicles are endowed with enhanced procoagulant activity in SARS-CoV-2 infection.

ABSTRACT:

Background

Coronavirus-2 (SARS-CoV-2) infection causes an acute respiratory syndrome accompanied by multi-organ damage that implicates a prothrombotic state leading to widespread microvascular clots. The causes of such coagulation abnormalities are unknown. The receptor tissue factor, also known as CD142, is often associated with cell-released extracellular vesicles (EV). In this study, we aimed to characterize surface antigens profile of circulating EV in COVID-19 patients and their potential implication as procoagulant agents.

Methods

We analyzed serum-derived EV from 67 participants who underwent nasopharyngeal swabs molecular test for suspected SARS-CoV-2 infection (34 positives and 33 negatives) and from 16 healthy controls (HC), as referral. A sub-analysis was performe

SUBMITTER: Balbi C 

PROVIDER: S-EPMC8104913 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature