Effects of Real-Ambient PM_2.5 Exposure on Lung Damage Modulated by Nrf2^-/.

ABSTRACT: Previous studies have shown that long-term exposure to fine particulate matter (PM_2.5) increases the morbidity and mortality of pulmonary diseases such as asthma, chronic obstructive pulmonary disease and pulmonary emphysema. Oxidative stress and inflammation play key roles in pulmonary damage caused by PM_2.5. Nuclear factor erythroid 2-related factor 2 (Nrf2) could regulate the expression of antioxidant and anti-inflammatory genes and is pivotal for protection against PM_2.5-induced oxidative stress. In this study, a real-ambient exposure system was constructed with the outdoor ambient air in north China. Wild-type (WT) and Nrf2^-/- (KO) mice were exposed to the real-ambient system for six weeks. After PM_2.5 exposure, our data showed th

SUBMITTER: Ding H 

PROVIDER: S-EPMC8104929 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature