A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy.

ABSTRACT:

Aims

In-stent restenosis is a complication after coronary stenting associated with morbidity and mortality. Here, we sought to investigate the molecular processes underlying neointima formation and to identify new treatment and prevention targets.

Methods and results

Neointima formation was induced by wire injury in mouse femoral arteries. High-accuracy proteomic measurement of single femoral arteries to a depth of about 5000 proteins revealed massive proteome remodelling, with more than half of all proteins exhibiting expression differences between injured and non-injured vessels. We observed major changes in the composition of the extracellular matrix and cell migration processes. Among the latter, we identified the classical transient receptor potential channel 6 (TRPC6)

SUBMITTER: Wierer M 

PROVIDER: S-EPMC8104955 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature