Persistent effects of pair bonding in lung cancer cell growth in monogamous Peromyscus californicus.

ABSTRACT: Epidemiological evidence suggests that social interactions and especially bonding between couples influence tumorigenesis, yet whether this is due to lifestyle changes, homogamy (likelihood of individuals to marry people of similar health), or directly associated with host-induced effects in tumors remains debatable. In the present study, we explored if tumorigenesis is associated with the bonding experience in monogamous rodents at which disruption of pair bonds is linked to anxiety and stress. Comparison of lung cancer cell spheroids that formed in the presence of sera from bonded and bond-disrupted deer mice showed that in monogamous Peromyscus polionotus and Peromyscus californicus, but not in polygamous Peromyscus maniculatus, the disruption of pair bonds altered

SUBMITTER: Naderi A 

PROVIDER: S-EPMC8104960 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature